Endocrine Abstracts

Objectives: To study the association of functional polymorphisms at DHFR, CBS and MTHFR genes with bone mineral density (BMD) and metabolic parameters of bone remodeling.Materials and methods: BMD (g/cm2) was measured by DEXA in 391 subjects: 174 with normal BMD (137F 37M; age=48.79±12.99 years; BMI=29.61±5.22 kg/m2), 62 with osteopenia (48F 14M; age=56.06±12.96 years; BMI=27.64±4.94 kg/m2) and 154 with osteoporosis (119F, 35M; age=64...

Objectives: The angiotensin-converting enzyme (ACE1) gene is one of the most studied genes in the pathogenesis of type II diabetes (T2DM) and cardiovascular disease. However, in the context of exerciSemodels in T2DM, they are not yet fully understood. We intended to characterize the genetic profile of individuals with T2DM from an inter-individual point of view using prognostic markers and cardiovascular risk. On the other hand, relate it with the profile obtained wit...

Introduction: Adrenocortical carcinoma is a rare endocrine disease characterized by an aggressive behaviour with a poor prognosis. Clinical experience, even with a little number of patients, has enhanced knowledge about this malignancy, in most cases challenging.Objective: Characterization of patients with adrenocortical carcinoma followed at the endocrine department of a hospital centre, between 1991 and 2019.Methods: Retrospectiv...